Charles A O'Brien, PhD
Disclosures: Nothing to disclose - 02/12/2022

Charles A. O’Brien, PhD

Professor of Medicine

Department of Internal Medicine

Department of Orthopaedic Surgery

VA Research Scientist


email: [email protected]


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I received my PhD in Microbiology and Immunology from the University of Oklahoma Health Sciences Center in 1990 and performed my postdoctoral training in the Department of Cell Biology at Yale University.  I joined the Division of Endocrinology at the University of Arkansas for Medical Sciences in 1994.  The primary focus of my laboratory has been to understand the cellular and molecular mechanisms that control bone remodeling, especially in conditions such as glucocorticoid excess and aging.  Most recently, our efforts have been focused on osteocytes. We have found that osteocytes produce RANKL, a factor that is essential for the differentiation of osteoclasts. Therefore, changes in RANKL production may be important for different types of pathological bone loss.  In all of these studies, we utilize genetically-modified mice, which have become an area of expertise for me and I served as director of the UAMS Genetic Models Core from 2004 to 2021.  I have been designing and generating transgenic mice since 1997, gene-targeted mice since 2004, and gene-edited mice since 2014.  My other major focus is the development and mentoring of junior faculty.  Our division has a strong record of helping early-stage investigators to develop productive programs and to achieve independent federal funding.  In 2018, we received P20 funding from NIH/NIGMS to expand these efforts and to develop the Center for Musculoskeletal Disease Research.  I have been funded by the NIH as a Principal Investigator since 1998 and by the Veteran’s Administration since 2009.



Complete list of published work also in GoogleScholar: